Research of Oscillating Magnetic Field Therapy

U.S. Patent 4,665,898: Malignancy Treatment

FDA report: Kinetics of Microbial Inactivation

U.S. Patent 4,524,079: Deactivation of Microorganisms by an Oscillating Magnetic Field

U.S. Patent 4,665,898
Inventor: Jonathan L. Costa, Gunter A. Hofmann
Date: May 19, 1987

Malignancy Treatment

Abstract

A body part of an animal afflicted with malignant cells is disposed within a magnetic coil and subjected to a plurality of magnetic field pulses, the pulses having intensities of between about l and about 100 Tesla and characteristic frequencies of between about 5 and about 100 kHz. The pulses magnetic field selectively inactivates and/or destroys malignant cells with relatively little damage to normal tissue.

Summary of the Invention
... Herein, it is discovered that high intensity magnetic fields applied in short pulses with moderate frequencies, can be used to selectively destroy or otherwise inactivate malignant cells within tissue of a living animal. Selective inactivation of malignant cells within animal tissue subjected to a pulsed magnetic field is accomplished without noticeable deterioration of gross characteristics of normal tissue.

Detailed Description of a Preferred Embodiment
It is found that subjecting body parts containing cancerous tissue to a plurality of magnetic field pulses, with characteristic frequencies above about 5 kHz and intensities above about 1 Tesla, will either arrest the growth of tumors or progressively reduce the number of cancerous cells, resulting in remission of tumors... The magnetic field in the coil is produced upon discharge of a bank of capacitors. The capacitor bank is charged from a source, and when a switch is closed... an oscillating current can be generated between the plates of the capacitors. The oscillating current, in turn, generates a pulsed magnetic field which is concentrated within the region bounded by the coil... Immediately subsequent to closing the switch, an intense magnetic field is produced by current flowing in one direction. As the current changes direction, the magnetic field changes polarity... The oscillating current and, hence, the oscillating magnetic field rapidly decreases after about ten oscillations dropping to a few percent of the original magnetic field strength. Herein, magnetic field intensities refer to the intensities of the initial peaks... The method is applicable to practically any type of tissue and is believed applicable for treatment of most types of malignancies... In each session, an animal is exposed to at least 1 and up to 1000 magnetic pulses. Generally a living animal would be subjected to at least ten pulses at each therapy session and up to one hundred pulses. An animal will be subjected to additional sessions until tumor remission is achieved... Malignant cells are more susceptible to destruction and/or inactivation by a pulsed intense electromagnetic field because the field may create eddy currents that are unique to the tumor. These localized eddy currents may cause effects that are deleterious to the viability and/or reproductive capability of the tumor cells. Alternatively, there may be macromolecules unique to malignant cells which are especially magnetically susceptible... Furthermore, treatment with a pulsed magnetic field does far less damage to the natural immune system than does radiation treatment or chemotherapy. Frequently, a patient who is treated extensively with ionizing radiation and/or with chemotherapy will experience an almost complete breakdown of the immune system. Subsequent to treatment, the immune system may take up to a year to recover, particularly with respect to immunity to viral infections. As a result, even if a patient is cured of the malignancy by radiation and/or chemotherapy, he is subject to debilitating disease or even death by infections to which his body would ordinarily have built up immunity. With the magnetic treatment described herein, here has been no evidence of major immune system beak-down.


TABLE 2

Evaluation of the Growth of Rat Mammary Tumors Following Multiple Exposures to a Rapidly Varying Magnetic Field

                                                              Partial or Complete Response
                                          Total                                                        Total Tumors
Tumor                              No. of        Interruption                        Responding
Type        Tesla/kHz      Tumors    of Growth      Shrinkage    No.    in percent

DMBA       5T / 8kHz            8                   2                       6                8        100% 
primary 

NMU          5T / 8kHz          10                   1                       9              10        100%
primary 

It can be seen from the above table that the method of the present invention is useful for treating a variety of malignancies, although the response varies according to the type of tumor. Accordingly, the method has general applicability to malignancy treatment.

Example 3
Twelve rats having primary DMBA-induced mammary carcinomas were treated daily with a conventional Magneform machine. A primary mammary gland carcinoma induced by a carcinogen, such as DMBA or NMU, is highly virulent, as outlined in substantial detail in P. M. Guillino, et al., Journal of the National Cancer Institute, Vol. 54, no. 2, February 1974. It is common for such a tumor in a rat to increase in size by about 10 to 30 fold in about 30 days, and if left untreated almost invariably will ulcerate within about 45 days. Ten of the rats are treated daily with 20 pulses at 5 Tesla and 8 KHz. Their tumor volumes on the 1st and 30th days are listed in with table 3 below:

TABLE 3


Test Tumor volume (cm3)
Rat Day 1 Day 30

1. 1.60 1.95
2. 1.20 3.65
3. 2.10 1.20
4. 1.40 3.81
5. .90 .42
6. 3.00 3.81
7. .38 .45
8. 2.10 8.18
9. 6.79 8.88
10. 1.10 .85
It can be seen from the above table that after thirty days the tumors were either diminished in size, stabilized, or at least controlled relative to untreated tumors... The remaining two rats were treated in an identical manner but at 1/4th the field intensity, i.e., 1.2 Tesla, 8 kHz, 20 pulses. One of these died on day 58 while the tumor size of the other had decreased in size from 1.6 cm3 on day 1 to 1.4 cm3 on day 62. The rats generally appeared to exhibit normal behavior and appetite and did not appear to lose weight. The fact that the rats did not die of infections suggested that the immune systems functioned normally.


Michael's Notes on Patent 4,665,898
This device produces the same type of oscillating magnetic field as does my OMF Generator. The basic design of mine is the same, with a capacitor (charged with high voltage) connected in parallel with a coil and spark plug to produce a decaying oscillating magnetic field. This patents device varies from mine in application only by the test subject being placed inside the coil, whereas mine was used so that the coil rests on the test subject which is effected by the lines of magnetic force emanating from the coil. Field force becomes less and less with more distance from the center of the coil as is indicated by the field force lines separating more. The results of test example 1 is a reduction of live cancer cells (in test tube) of 32% of undifferentiated carcinoma and 29% of embryonic carcinoma after 18 days. This was after 8 pulses of oscillating magnetic field of 5 Tesla at 8000 hertz on day 1. The results of test example 2 is 75% and 90% of treated rat mammary tumors (6 of 8 DMBA primary tumors, and 9 of 10 NMU primary tumors) shrunken after 20 pulses daily of OMF at 5 Tesla and 8000 hertz for 6 days. The results of test example 3 is an average 86% reduction of tumor size after 30 days (compared to a typical 20 times tumor growth after 30 days). Treatment was with 20 pulses OMF of 5 Tesla at 8000 hertz daily for 30 days. Tumors were induced by injection of the DMBA chemical. The table below has columns for the typical 20x size after 30 days and the percent reduction of the treated tumors compared to the 20x size. It also shows the equally positive lower intensity (1.2 Tesla) test results on one tumor with a resultant 96% reduction.



TABLE 3
      Tumor Volume (cm3) .
 
                     typical size after 30 days     percent
Rat   Day 1   Day 30    if left untreated (x20 size)   reduction

 l.   1.60    1.95             32.                     94% 
 2.   1.20    3.65             24.                     85% 
 3.   2.10    l.20             42.                     97% 
 4.   1.40    3.81             28.                     86% 
 5.    .90     .42             18.                     98% 
 6.   3.00    3.81             60.                     94% 
 7.    .38     .45              7.6                    94% 
 8.   2.10    8.18             42.                     8l% 
 9.   6.79    8.88             13.6                    35% 
l0.   1.1      .85             22.                    96% 
                                               average 86% 

treatment with 20 pulses of 1.2 Tesla at 8 kHz for 30 days 
11.   l.6     1.40             32.                     96% 

 

 


U.S. Food and Drug Administration
Center for Food Safety and Applied Nutrition
June 2, 2000

Kinetics of Microbial Inactivation for Alternative Food Processing Technologies Oscillating Magnetic Fields



Scope of Deliverables
This section reports the effects of magnetic fields on microbial populations.

1. Definition, Description and Application
Static (SMF) and oscillating (OMF) magnetic fields have been explored for their potential as microbial inactivation methods... an OMF is applied in the form of constant amplitude or decaying amplitude sinusoidal waves. OMF applied in the form of pulses reverse the charge for each pulse, and the intensity of each pulse decreases with time to about 10% of the initial intensity (Pothakamury and others 1993). Preservation of foods with OMF involves sealing food in a plastic bag and subjecting it to 1 to 100 pulses in an OMF with a frequency between 5 to 500 kHz at temperatures in the range of 0 to 50 degrees Celsius for a total exposure time ranging from 25 to 100 milliseconds. OMF of intensity of 5 to 50 tesla (T) and frequency of 5 to 500 kHz (5000 - 500,000) was applied and reduced the number of microorganisms by at least 2-log cycles (1/100th ). OMF of this intensity can be generated using: (1) superconducting coils; (2) coils which produce DC fields or (3) coils energized by the discharge of energy stored in a capacitor (Gersdof and others 1983). Inhibition or stimulation of the growth of microorganisms exposed to magnetic fields may be a result of the magnetic fields themselves or the induced electric fields. The latter is measured in terms of induced electric field strength and induced current density.

2. Inactivation of Microorganisms
Table 1. Effect of magnetic fields in microorganisms.


                                type of
field     frequency   magnetic  micro-
strength   of pulse   field     organism         Effect                  Reference
12 tesla     6000     OMF      Streptococcus   Cell population reduced    Moore (1985)
           (1 pulse)           Themophilus     from 25,000 cells/ml to  
                               in milk         970

7.5 tesla    8500     OMF      Mold spores     Population reduced from    Hofmann (1985)
           (1 pulse)                           3,000 spores/ml to 1  

Hofmann (1985) reported on the inactivation of microorganisms with OMF in milk, yogurt, orange juice and bread roll dough. According to Hofmann (1985) only 1 pulse of OMF was adequate to reduce the bacterial population to between 1% and .1%.

References  

Hofmann G.A. 1985. Deactivation of microorganisms by an oscillating magnetic field. 

U.S. Patent 4,524,079. Moore, R.L. 1979. Biological effects of magnetic fields Studies with microorganisms. Can. J. Microbiol., 25:1145-1151 

Gersdorf, R., deBoer, F.R., Wolfrat, J.C., Muller, F.A., Roeland, L. W. 1983. The high magnetic facility of the University of Amsterdam, high field magnetism. Proceedings International Symposium on High Field Magnetism. Osaka, Japan. 277-287 

Pothkamury, U.R., Barbosa-Canovas, G.V., and Swanson, B.G. (1993). Magnetic-field inactivation of microorganisms and generation of biological changes. Food Technol. 47(12):8593 

Michael's Notes: This papers test results revealing effectiveness against bacteria and fungi/mold, and patent 4,524,079, is what inspired me to create my own version of the mentioned device. The OMF Generator I sell is an oscillating magnetic field generator (with an OMF of decaying amplitude as Hofmann and Moore used) with a magnetic field strength of around .9 Tesla and a frequency of around 7200 cycles per second (7.2 KHz). Its electromagnetic coil is energized by the discharge of energy stored in a capacitor. The experiences of myself and others with the OMF Generator are in agreement with the scientific test results of Moore and Hofmann in that it appeared effective against bacteria and mold (fungus) although our test medium was human tissue instead of food. Their test results showed a 96% reduction of streptococcus bacteria (at 6kHz/12T) and a 99.9% reduction of mold spores (at 8.5kHz/7.5T).



U.S. Patent 4,524,079
Inventor: Gunter A. Hofmann
Date: June 18, 1985

Deactivation of Microorganisms by an Oscillating Magnetic Field

Abstract
Material... such as food products... is disposed within a magnetic coil and subjected to one or more pulses of an oscillating magnetic field having an intensity of between 2 and about 100 Tesla and a frequency of between 5 and about 500 kHz. A single pulse of the magnetic field generally decreases the microorganism population by at least about two orders of magnitude. [1/100th]

Detailed Description of a Preferred Embodiment
The magnetic field in the coil is produced upon discharge of a capacitor. The capacitor is charged from a source, and when a switch is closed... an oscillating current is generated between the plates of the capacitor. The oscillating current in turn generates an oscillating magnetic field which is concentrated within the region bounded by the coil... Immediately subsequent to closing the switch, an intense magnetic field is produced by current flowing in one direction. As the current changes direction, the magnetic field changes polarity. The oscillating current and, hence, the oscillating magnetic field rapidly deteriorates, with the field intensity after about ten oscillations dropping to a few percent of the original intensity. Herein, magnetic field intensities refer to the intensity of the initial peaks... Herein pulse duration is considered to be 10 oscillations, after which the substantially decayed field has a negligible effect.

Example 1
A sample of pasteurized milk is... inoculated with Streptococcus thermophilus at a concentration of 25,000 bacterium/cm3... The milk is subjected to 1 pulse of a 12 Tesla, 6kHz, oscillating magnetic field... An aliquot of the milk is plated on a standard plate. The colony count of the plate shows a concentration of about 970 Streptococcus thermophilus per cm3.

Example 2
350g of plain 4% fat yogurt is opened, inoculated with Saccharomyces at a concentration of 3,500 bacteria/cm3 and stirred thoroughly. The container full of inoculated yogurt is placed centrally within the coil described above and subjected to 10 pulses of a 40 Tesla, 416 kHz oscillating magnetic field. A sample of the yogurt is plated on standard plates, and a count of the cultures reveals a concentration of only about 25 Saccharomyces bacteria per cm3 of yogurt.

Example 4
A prepackaged dough product... is thoroughly mixed with mold spores to give a concentration of 3000 spores/cm3. The chopped rolls... was centered in the above-described coil where it was subjected to l pulse of 7.5 Tesla, 8.5 kHz, oscillating magnetic field. A sample of the chopped rolls is plated on standard plates, and a culture count shows a mold spore concentration of only about 1 spore per cm3.


Michael's Notes on Patent 4,524,079
This device produces the same type of oscillating magnetic field as does my OMF Generator. The basic design of mine is the same, with a capacitor (charged with high voltage) connected in parallel with a coil and spark plug to produce a decaying oscillating magnetic field. This patents device varies from mine in application only by the test product being placed inside the coil, whereas mine is used so that the coil rests on the test subject which is effected by the lines of magnetic force emanating from the coil. Field force becomes less and less with more distance from the center of the coil. The patents results of test example 1 is a 96% reduction of bacteria (from 25,000 to 970). The patents results of test example 2 is a 99.3% reduction of bacteria (from 3,500 to 25). The results of test example 4 is a 99.9% reduction of fungi spores (from 3000 to l ).
 

 

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